克罗米酚对男性低促性腺素自闭症减退症有效

纽约（路透社生活品质版）1同月四日华盛顿邮报：据发表在12同月出版发行的《生育与子代》同月刊的一项通报指出克罗米酯类对其余部分低促持续性腺素在持续高血压升高的男持续性病人稳定。来自布里斯托尔阿拉巴马大学的该通报的第一笔记Scott J. WhittenDr在接纳路透通讯社采访时知道：“原发持续性或获得持续性HH病人在接纳侵害持续性更大和更为较贵的用药（例如注射促持续性腺激素在类）前透过4个同月的克罗米酯类试验持续性用药是稳定的。”WhittenDr和同事研究者了克罗米酯类对10名HH男持续性病人（HH是导致男持续性子代的常见因素在）究竟适当。通报称克罗米酯类用药1年后，4名卡尔曼(氏)综合征病人中只有一名病人的精子浓度增加而全垂体功能升高症病人的精子缺少患者外没有得到提高。无论如何，该通报指出3名孩童发病的原发持续性HH男持续性病人经过3个同月克罗米酯类的用药精子浓度有了明显增加。目前为止该组病人已为两名丧失了不孕。WhittenDr知道：“除非对克罗米酯类用药没有反应，我们不会因为副作用中止对病人使用该药物。”之前笔记回顾知道：“因为条件局限，对HH病人促持续性腺激素在类药物和克罗米酯类的随机研究者容易透过，然而利用多第一部的恰当同样规格对病人透过规格意味著借助进一步验证克罗米酯类丧失男持续性低不孕的适当持续性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

撰稿：蓝色妄想

撰稿： 张靖